ABCD Study and Course Motivation
The Adolescent Brain Cognitive Development (ABCD) Study® is the largest long-term study of brain development and child health in the United States. The National Institutes of Health (NIH) funded leading researchers in the fields of adolescent development and neuroscience to conduct this ambitious project. The ABCD Research Consortium consists of a Coordinating Center, a Data Analysis, Informatics & Resource Center, and 21 research sites across the country. The ABCD Consortium has invited 11,878 children ages 9-10 to join the study and researchers are tracking their biological and behavioral development through adolescence into young adulthood. ABCD protocol summaries describe the physical, cognitive, social, emotional, environmental, behavioral, and academic assessments, as well as multimodal neuroimaging and biospecimen collection for hormonal, genetic, epigenetic, environmental exposure, and substance use analysis.
One goal of the multisite, longitudinal ABCD Study® is to create a unique data resource for the entire scientific community by embracing an open science model. However, an increasing body of evidence points to some issues in reproducibility in biomedical or life sciences. The issue of lack of reproducibility has been now described in several scientific domains, and for several years raising concerns in the scientific community. ReproNim, a Center for Reproducible Neuroimaging Computation, aims to help researchers achieve more reproducible data analysis workflows and outcomes. ReproNim has developed a curriculum that gives researchers the information, tools and practices to perform repeatable and efficient research, and a map of where to find the resources for deeper practical training.
The ABCD-ReproNim course was designed to provide a comprehensive background to the ABCD dataset while delivering hands-on, interactive instruction to enable rigorous and reproducible data analyses. We assembled an interdisciplinary team of instructors and evaluators that included ABCD Study® Investigators, ReproNim team members and collaborators, and non-ABCD/ReproNim researchers. The ABCD-ReproNim Course resulted in a cadre of investigators well trained in analyzing ABCD data in ways that support efficient, re-executable design and FAIR practices.
ABCD-ReproNim was supported by an award from the National Institute of Drug Abuse (R25-DA051675).